Can you find out a relation and tell which number will suffice the pattern?

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In the given figure, you can see that there are four circles numbered from 1 to 4. In the fourth circle, a digit is missing. Can you find out a relation and tell which number will suffice the pattern?

If we tell you that there is a relation between the numbers and letters in the given figure, can you analyze it and find the missing letter in the last box?